{"id":5580,"date":"2026-10-26T12:42:30","date_gmt":"2026-10-26T16:42:30","guid":{"rendered":"https:\/\/canasanta.ca\/?p=5580"},"modified":"2026-10-26T12:42:30","modified_gmt":"2026-10-26T16:42:30","slug":"nuevo-farmaco-alarga-vida-cancer-endometrio","status":"publish","type":"post","link":"https:\/\/canasanta.ca\/en\/salud\/nuevo-farmaco-alarga-vida-cancer-endometrio\/","title":{"rendered":"UN NUEVO F\u00c1RMACO ALARGA LA VIDA EN C\u00c1NCER DE ENDOMETRIO"},"content":{"rendered":"

Un medicamento experimental de Merck ha logrado prolongar de manera significativa la supervivencia de pacientes con c\u00e1ncer de endometrio avanzado que ya hab\u00edan recibido tratamiento. Sacituzumab tirumotecan, conocido como sac-TMT, redujo en un 32% el riesgo de muerte frente a la quimioterapia est\u00e1ndar en un ensayo cl\u00ednico fase III con 776 pacientes.<\/p>\n

Los resultados, divulgados este 26 de octubre, llevaron adem\u00e1s a la Administraci\u00f3n de Alimentos y Medicamentos de Estados Unidos (FDA) a conceder al tratamiento una revisi\u00f3n prioritaria. Eso acelera la evaluaci\u00f3n regulatoria, pero no significa que el medicamento haya sido aprobado todav\u00eda.<\/p>\n

 <\/p>\n

SIETE MESES M\u00c1S DE SUPERVIVENCIA<\/strong><\/h3>\n

En el estudio, las pacientes tratadas con sac-TMT alcanzaron una supervivencia global mediana de 19 meses, frente a 12,1 meses entre quienes recibieron quimioterapia. La diferencia representa una reducci\u00f3n del 32% en el riesgo de muerte durante el periodo analizado.<\/p>\n

Tambi\u00e9n mejor\u00f3 el tiempo durante el cual la enfermedad permaneci\u00f3 sin progresar. La supervivencia libre de progresi\u00f3n fue de 7,2 meses con sac-TMT, comparada con 3,9 meses en el grupo de quimioterapia, lo que equivale a una reducci\u00f3n del 41% en el riesgo de progresi\u00f3n o muerte.<\/p>\n

 <\/p>\n

LOS TUMORES RESPONDIERON EL DOBLE<\/strong><\/h3>\n

La respuesta tumoral fue otro de los resultados destacados. Los tumores disminuyeron de tama\u00f1o en el 35% de las pacientes que recibieron sac-TMT, frente al 17% de las tratadas con quimioterapia convencional.<\/p>\n

El medicamento pertenece a una clase de terapias conocidas como conjugados anticuerpo-f\u00e1rmaco. Est\u00e1 dise\u00f1ado para dirigirse a TROP2, una prote\u00edna presente en numerosos tumores endometriales, y transportar directamente una carga terap\u00e9utica hacia las c\u00e9lulas cancerosas.<\/p>\n

 <\/p>\n

EL BENEFICIO TAMBI\u00c9N TIENE UN COSTO<\/strong><\/h3>\n

La mejora en supervivencia vino acompa\u00f1ada de una mayor frecuencia de efectos adversos graves relacionados con el tratamiento. Estos aparecieron en el 54% de las pacientes tratadas con sac-TMT, frente al 41% de quienes recibieron quimioterapia.<\/p>\n

Ese balance entre eficacia y toxicidad ser\u00e1 uno de los elementos centrales que deber\u00e1 valorar la FDA. La revisi\u00f3n prioritaria acorta los plazos administrativos para medicamentos que podr\u00edan representar una mejora importante, pero la agencia todav\u00eda debe determinar si los beneficios justifican los riesgos.<\/p>\n

 <\/p>\n

LA FDA ACELERA SU DECISI\u00d3N<\/strong><\/h3>\n

Merck desarrolla sac-TMT junto con la biotecnol\u00f3gica china Kelun-Biotech. La compa\u00f1\u00eda espera una decisi\u00f3n regulatoria estadounidense a m\u00e1s tardar en junio de 2027, aunque la designaci\u00f3n de revisi\u00f3n prioritaria abre la posibilidad de una resoluci\u00f3n anterior.<\/p>\n

El c\u00e1ncer de endometrio se origina en el revestimiento interno del \u00fatero y es el c\u00e1ncer uterino m\u00e1s frecuente. Aunque muchos casos se detectan en etapas tempranas y pueden tratarse con cirug\u00eda, la enfermedad avanzada o recurrente contin\u00faa siendo mucho m\u00e1s dif\u00edcil de controlar.<\/p>\n

Los resultados no convierten todav\u00eda a sac-TMT en un tratamiento disponible para uso general. S\u00ed colocan al f\u00e1rmaco ante una prueba decisiva: demostrar ante los reguladores que siete meses adicionales de supervivencia mediana pueden traducirse en una nueva opci\u00f3n real para pacientes cuyo c\u00e1ncer ha regresado o progresado despu\u00e9s de tratamientos previos.<\/p>","protected":false},"excerpt":{"rendered":"

Un f\u00e1rmaco experimental de Merck prolong\u00f3 la supervivencia en c\u00e1ncer de endometrio avanzado y recibi\u00f3 revisi\u00f3n prioritaria de la FDA.<\/p>","protected":false},"author":284226809,"featured_media":5581,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[33205457,2127],"tags":[33207606,33205885,33207492,33207607],"class_list":["post-5580","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-al-dia","category-salud","tag-cancer-endometrio","tag-fda","tag-merck","tag-sacituzumab-tirumotecan"],"acf":{"introduccion":"","fuentes_y_referencias":"

Fuentes<\/strong><\/h3> Reuters \u2014 \u2018Merck drug extends survival in endometrial cancer trial, wins US priority review\u2019, 26 de octubre de 2026. National Cancer Institute \u2014 \u2018What Is Endometrial Cancer?\u2019, informaci\u00f3n cl\u00ednica sobre c\u00e1ncer de endometrio. 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