{"id":1171,"date":"2026-09-17T01:46:35","date_gmt":"2026-09-17T05:46:35","guid":{"rendered":"https:\/\/canasanta.ca\/?p=1171"},"modified":"2026-09-17T01:46:35","modified_gmt":"2026-09-17T05:46:35","slug":"logran-integrar-tejido-cerebral-humano-en-ratones","status":"publish","type":"post","link":"https:\/\/canasanta.ca\/en\/al-dia\/logran-integrar-tejido-cerebral-humano-en-ratones\/","title":{"rendered":"RESEARCHERS SUCCEED IN INTEGRATING HUMAN BRAIN TISSUE INTO MICE"},"content":{"rendered":"

 <\/p>\n

Un equipo encabezado por investigadores de Stanford ha conseguido que tejido cerebral humano cultivado en laboratorio crezca y se integre en el sistema nervioso de ratones modificados gen\u00e9ticamente. El estudio, publicado el 16 de septiembre en Nature, permite observar c\u00f3mo se desarrollan y funcionan esas c\u00e9lulas dentro de un organismo vivo.<\/p>\n

Los cient\u00edficos emplearon organoides corticales: peque\u00f1as estructuras tridimensionales obtenidas a partir de c\u00e9lulas madre humanas que reproducen algunos aspectos de la corteza cerebral en desarrollo. Los trasplantaron a ratones reci\u00e9n nacidos cuya modificaci\u00f3n gen\u00e9tica imped\u00eda la formaci\u00f3n de gran parte de su neocorteza e hipocampo.<\/p>\n

El tejido implantado ocup\u00f3 buena parte del espacio disponible y desarroll\u00f3 actividad el\u00e9ctrica organizada. A los tres meses, representaba aproximadamente el 92 % del volumen cortical medido en siete animales.<\/p>\n

La precisi\u00f3n importa: ese porcentaje corresponde al tejido cortical presente, no al cerebro completo. El experimento tampoco demuestra que los animales hayan adquirido pensamiento o conciencia humanos. Los investigadores observaron integraci\u00f3n neuronal y cambios espec\u00edficos en el comportamiento, no una transformaci\u00f3n del rat\u00f3n en un organismo con capacidades humanas. Estudio original en Nature<\/a>.<\/p>\n

 <\/p>\n

UNA VENTANA AL DESARROLLO CEREBRAL<\/em><\/h4>\n

Estudiar tejido cerebral humano vivo es especialmente dif\u00edcil. Los cultivos de laboratorio permiten investigar c\u00e9lulas y circuitos, pero carecen de muchas condiciones que ofrece un organismo, como el suministro sangu\u00edneo y las conexiones con otros sistemas.<\/p>\n

El equipo de Sergiu Pa\u0219ca busca superar parte de esas limitaciones. Seg\u00fan Stanford Medicine, las c\u00e9lulas trasplantadas sobrevivieron, maduraron y establecieron conexiones con el sistema nervioso de los animales.<\/p>\n

Para explorar la utilidad del modelo, los investigadores expusieron a los ratones a un ambiente con poco ox\u00edgeno durante cinco horas. El tejido cortical de origen humano sufri\u00f3 da\u00f1os importantes y los animales mostraron dificultades para mantener una marcha estable y el equilibrio. Los grupos de comparaci\u00f3n resultaron mucho menos afectados.<\/p>\n

Ese resultado podr\u00eda ayudar a estudiar por qu\u00e9 las c\u00e9lulas nerviosas humanas son vulnerables a la falta de ox\u00edgeno durante etapas tempranas del desarrollo. Los autores consideran que el modelo puede servir para investigar mecanismos relacionados con la par\u00e1lisis cerebral y evaluar posibles intervenciones.<\/p>\n

Por ahora, el logro es una herramienta experimental. No constituye una cura ni demuestra que una terapia sea segura o eficaz en pacientes. Stanford Medicine<\/a>.<\/p>\n

 <\/p>\n

EL AVANCE TAMBI\u00c9N EXIGE SUPERVISI\u00d3N<\/em><\/h4>\n

La posibilidad de cultivar tejido nervioso humano y trasplantarlo a animales plantea preguntas que la comunidad cient\u00edfica lleva a\u00f1os examinando. Entre ellas figuran las condiciones bajo las que deben autorizarse estos experimentos, el consentimiento de los donantes y la aparici\u00f3n de propiedades que requieran nuevas formas de evaluaci\u00f3n.<\/p>\n

Un informe sobre una reuni\u00f3n celebrada en Asilomar en 2025, presentado este septiembre por el Instituto Wu Tsai de Stanford, propone construir una estructura internacional de supervisi\u00f3n para la investigaci\u00f3n con organoides y ensamblajes de tejido neural.<\/p>\n

Sus participantes incluyeron cient\u00edficos, especialistas en \u00e9tica, representantes de pacientes y otras voces de la sociedad civil. Recomendaron mecanismos capaces de revisar los avances de manera continua, ofrecer orientaci\u00f3n pr\u00e1ctica y adaptar las reglas cuando surjan nuevas cuestiones.<\/p>\n

El reto consiste en acompa\u00f1ar una tecnolog\u00eda que puede ampliar el conocimiento de enfermedades dif\u00edciles de estudiar, sin dejar que su velocidad supere la capacidad de evaluarla. La participaci\u00f3n p\u00fablica y la rendici\u00f3n de cuentas forman parte de ese esfuerzo. Instituto Wu Tsai de Neurociencias<\/a>.<\/p>","protected":false},"excerpt":{"rendered":"

  Un equipo encabezado por investigadores de Stanford ha conseguido que tejido cerebral humano cultivado en laboratorio crezca y se integre en el sistema nervioso de ratones modificados gen\u00e9ticamente. El estudio, publicado el 16 de septiembre en Nature, permite observar c\u00f3mo se desarrollan y funcionan esas c\u00e9lulas dentro de un organismo vivo. Los cient\u00edficos emplearon […]<\/p>\n","protected":false},"author":284226809,"featured_media":1173,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[33205457,3213],"tags":[33205469,33205467,10921,33205466,33205468],"class_list":["post-1171","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-al-dia","category-ciencia","tag-bioetica","tag-cerebro","tag-investigacion","tag-neurociencia","tag-stanford"],"acf":{"introduccion":"

Las c\u00e9lulas trasplantadas crecieron y formaron conexiones con el sistema nervioso de los animales. El avance ofrece una nueva herramienta para investigar el desarrollo cerebral y las enfermedades neurol\u00f3gicas.<\/strong><\/em><\/h2>","fuentes_y_referencias":"","autor":[748]},"yoast_head":"\nLOGRAN INTEGRAR TEJIDO CEREBRAL HUMANO EN RATONES - Ca\u00f1asanta<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/canasanta.ca\/en\/daily\/logran-integrar-tejido-cerebral-humano-en-ratones\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"LOGRAN INTEGRAR TEJIDO CEREBRAL HUMANO EN RATONES\" \/>\n<meta property=\"og:description\" content=\"  Un equipo encabezado por investigadores de Stanford ha conseguido que tejido cerebral humano cultivado en laboratorio crezca y se integre en el sistema nervioso de ratones modificados gen\u00e9ticamente. El estudio, publicado el 16 de septiembre en Nature, permite observar c\u00f3mo se desarrollan y funcionan esas c\u00e9lulas dentro de un organismo vivo. 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